comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

نویسندگان

gholamhossein yousefi department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran

center for nanotechnology in drug delivery, shiraz university of medical sciences, shiraz, iran

mohammad bizhani international branch, shiraz university of medical sciences, shiraz, iran

akram jamshidzadeh department of pharmacology and toxicology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran

چکیده

objective(s): comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (amt) on activated charcoal (ac) and sodium polystyrene sulfonate (sps). ac has been long used as gastric decontamination agent for tricyclic antidepressants and sps has showed to be highly effective on in-vitro drugs adsorption. materials and methods: sprague-dawley male rats were divided into six groups. group i: control, group ii: amt 200 mg/kg as single dose orally, group iii and iv: ac 1g/kg as single dose orally 5 and 30 min after amt administration respectively, and group 5 and 6: sps 1 g/kg as single dose orally 5 and 30 min after amt administration, respectively. 60 min after oral administration of amt (tmax of amt determined in rats), cmax plasma levels were determined by a validated gc-mass method. results: the cmax values for groups ii to iv were determined as 1.1, 0.5, 0.6, 0.1 and 0.3 µg/ml, respectively. conclusion: ac and sps could significantly reduce cmax of amt when administrated either 5 or 30 min after amt overdose (p<0.05). however, sps showed to be more effective than ac in reducing cmax when was administrated immediately (5 min) after amt overdose. the results suggest a more efficient alternative to ac for amt and probably other tca overdoses.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. Materials and Methods: Sprague-Dawley male rats...

متن کامل

Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

OBJECTIVES Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. MATERIALS AND METHODS Sprague-Dawley male rats w...

متن کامل

Commentary: Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

Dear editor We read with interest the recent article by Yousefi et al “Comparison of activated charcoal (AC) and sodium polystyrene sulfonate (SPS) resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities” (1). While we commend the authors for studying the important issue of gastrointestinal decontamination, we have a few concerns with this...

متن کامل

assessment of deep word knowledge in elementary and advanced iranian efl learners: a comparison of selective and productive wat tasks

testing plays a vital role in any language teaching program. it allows teachers and stakeholders, including program administrators, parents, admissions officers and prospective employers to be assured that the learners are progressing according to an accepted standard (douglas, 2010). the problems currently facing language testers have both practical and theoretical implications but the first i...

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۲۰، شماره ۱، صفحات ۴۶-۵۲

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023